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Table 1 Characteristics of included randomized controlled trials

From: The effect of donor human milk on the length of hospital stay in very low birthweight infants: a systematic review and meta-analysis

Authors

Year

n of Infants

Design

Inclusion criteria

Gestational age, week

Primary outcome(s)

Intervention

Duration of intervention/observation

Length of hospital stay, days (mean ± SD)

Fortification

Comments

Schanler et al. [37]

2005

243

Single blinded

GA ≤ 29 weeks

27 ± 2/

27 ± 2

Incidence of late-onset; sepsis and NEC

Exclusively MOM

MOM + DHM

MOM + PF

90 days or discharge.

85.0 ± 53.0/ 90.0 ± 56.0

Bovine fortifier added to DHM group.

According to established criteria, DHM and PF groups were included.

O’Connor et al. [35]

2016

363

Double blinded

BW < 1500 g, enteral feeding within 7 day

27.5 ± 2.4/

27.8 ± 2.7

Bayley-III score at 18 month; the incidence of NEC

MOM + DHM

MOM + PF

90 days or discharge.

77.2 ± 53.0/ 73.2 ± 39.2

Bovine fortifier added to DHM group.

MOM + DHM group:

MOM = 58%

MOM + PF group:

MOM = 63%

Cristofalo et al. [36]

2013

53

Double blinded

BW < 1250 g

27.7 ± 1.5/

27.5 ± 2.4

Duration of parenteral nutrition; the incidence of NEC

Exclusive DHM

Exclusive PF

91 days of age or discharge, or ≥ 50% oral feedings.

80.0 ± 32.1/ 90.0 ± 50.2

DHM fortifier added to DHM group.

 

Sullivan et al. [32]

2010

207

Single blinded

BW 500–1250 g, intention to provide MOM.

27.2 ± 2.2/

27.3 ± 2.0

The incidence of NEC; parenteral nutrition, days; length of stay, days; bronchopulmonary dysplasia; weight gain

MOM+DHM MOM + PF

91 days or oral feedings or discharge.

80.1 ± 34.8/ 81.3 ± 24.2

Donor added to DHM group; bovine fortifier added to PF group.

Group HM100 and group PF received fortifier when enteral intake was 100 mL/kg/d. The gestational week refers to the two groups rincluded.

  1. MOM mother’s own milk, PF preterm formula, DHM donor human milk, HM human milk, GA gestational age, BW birth weight, NEC necrotizing enterocolitis