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Table 3 The interrelation between Sirtuin3, 8-hydroxy-2-deoxyguanosine, brain-derived neurotrophic factor and serotonin in early breast milk of mothers giving birth at term vaginally or by Caesarean section and those delivering preterm (Spearman’s rank correlation)

From: Effects of perinatal factors on sirtuin 3, 8-hydroxy-2′- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study

 

Vaginal birth at term

Caesarean section at term

Preterm birth

SIRT3

8-OHdG

BDNF

5-HT

SIRT3

8-OHdG

BDNF

5-HT

SIRT3

8-OHdG

BDNF

5-HT

Biomarkers in breast milk

 SIRT3

R

 

0.41*

−0.20

0.48*

 

0.50**

0.05

0.40*

 

0.40*

−0.20

0.54**

p

 

0.04

0.34

0.01

 

0.006

0.81

0.03

 

0.03

0.26

0.001

 8-OHdG

R

0.41*

 

−0.29

0.78**

0.50**

 

−0.08

0.43*

0.40*

 

−0.26

0.40*

p

0.04

 

0.16

0.000

0.01

 

0.67

0.02

0.03

 

0.15

0.02

 BDNF

R

−0.20

−0.29

 

−0.34

0.05

−0.08

 

−0.17

− 0.20

− 0.26

 

− 0.26

p

0.34

0.16

 

0.09

0.81

0.67

 

0.37

0.26

0.15

 

0.15

 5HT

R

0.48*

0.78**

−0.34

 

0.40*

0.43*

−0.17

 

0.54**

0.40*

−0.26

 

p

0.01

0.000

0.09

 

0.03

0.02

0.37

 

0.001

0.02

0.15

 
  1. SIRT3 Sirtuin 3, 8-OHdG 8-hydroxy-2′-deoxyquanosine, BDNF Brain-derived neurotrophic factor, 5-HT Serotonin
  2. **= p < 0.01, *= p < 0.05