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Table 2 Cord blood and early breast milk levels of Sirtuin3 (Sirt3), 8-hydroxy-2-deoxyguanosine (8OHdG), brain-derived neurotrophic factor (BDNF) and serotonin (5HT) of mothers giving birth at term vaginally or by Caesarean section and those delivering preterm (median with 25th and 75th centiles)

From: Effects of perinatal factors on sirtuin 3, 8-hydroxy-2′- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study

 

SIRT 3 (ng/ml)

8-OHdG (pg/ml)

BDNF (ng/ml)

5-HT (ng/ml)

Compared Groups

I. Venous cord blood

 

p = 0.001**

X2 = 13.61

 

p < 0.001**

X2 = 21.82

 

p < 0.001**

X2 = 38.55

 

p = 0.09

X2 = 4.91

1–2-3

 1. Vaginal birth at term (N = 27)

0.27 (0.23;034)

p = 0.224

Z = -1.22

7.42 (0.05;14.41)

p = 0.54

Z = -0.61

77.94 (64.03;119.09)

p = 0.007**

Z = -2.72

90.96 (55.53;110.64)

p = 0.57

Z = -0.57

1–2

 2. Caesarean section at term (N = 29)

0.24 (0.18;0.31)

p = 0.02*

Z = -2.41

8.41 (1.34,15.48)

p < 0.001**

Z = -3.68

57.22 (54.76;76.80)

p < 0.001**

Z = -4.68

73.55 (56.59;107.29)

p = 0.10

Z = -0.1.64

2–3

 3. Preterm birth (N = 28)

0.20 (0.15;0.24)

p < 0.001**

Z = -3.62

21.10 (11.63;26.87)

p < 0.001**

Z = -4.28

36.22 (24.83;47.17)

p < 0.001**

Z = -5.40

58.39 (45.52;90.70)

p = 0.04*

Z = -2.07

1–3

II. Breast milk

 

p = 0.184

X2 = 3.39

 

p = 0.01**

X2 = 9.55

 

p = 0.03*

X2 = 7.23

 

p = 0.02*

X2 = 8.03

1–2-3

 1. Vaginal birth at term (N = 27)

0.34 (0.17;1.27)

p = 0.06

Z = -1.94

13.29 (4.15;30.45)

p = 0.09

Z = -1.68

0.97 (0.76;1.11)

p = 0.68

Z = -0.42

14.69 (6.13;24.10)

p = 0.48

Z = -0.70

1–2

 2. Caesarean section at term (N = 29)

1.72 (0.26;5.25)

p = 0.80

Z = -0.25

7.76 (3.20;17.6)

p = 0.002**

Z = -3.11

0.24 (0.20;0.94)

p = 0.02*

Z = -2.39

8.65 (3.43;23.35)

p = 0.01*

Z = -2.50

2–3

 3. Preterm birth (N = 28)

2.19 (0.23;5.77)

p = 0.22

Z = -1.23

15.30 (10.85;35.97)

p = 0.24

Z = -1.17

0.03 (0.02;0.11)

p = 0.008**

Z = -2.65

25.82 (11.04;34.72)

p = 0.02*

Z = -2.25

1–3

I-II. Cord blood and breast milk

 1. Vaginal birth at term (N = 27)

 

p = 0.08

Z = -1.75

 

p = 0.01*

Z = -2.46

 

p = 0.03*

Z = -2.20

 

p < 0.001**

Z = -4.37

 

 2. Caesarean section at term (N = 29)

 

p < 0.001**

Z = -3.80

 

p = 0.61

Z = -0.51

 

p = 0.02*

Z = -2.37

 

p < 0.001**

Z = -4.76

 

 3. Preterm birth (N = 28)

 

p < 0.001**

Z = -4.00

 

p = 0.70

Z = -0.38

 

p < 0.001**

Z = -4.78

 

p < 0.001**

Z = -4.74

 
  1. Comparisons between three groups (1,2,3) by Kruskal-Wallis test, between two groups (1–2 or 2–3 or 1–3) by Mann-Whitney U test and between venous cord blood and breast milk (I-II.) were done by Wilcoxon test
  2. **= p < 0.01, *= p < 0.05