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Table 2 Macronutrient and energy content in preterm and term human milk (n = 45) during the daytime

From: Circadian changes in the composition of human milk macronutrients depending on pregnancy duration: a cross-sectional study

 

Time of day (hours)

6 AM – 12 PM

6 AM – 6 PM

6 AM – 12 AM

12 PM – 6 PM

12 PM – 12 AM

6 PM – 12 AM

Protein, g/100 mL

\( \overline{x}\pm s \)

1.37 ± 0.2

1.43 ± 0.2

1.37 ± 0.2

1.41 ± 0.2

1.37 ± 0.2

1.37 ± 0.2

1.43 ± 0.2

1.41 ± 0.2

1.43 ± 0.2

1.37 ± 0.2

1.41 ± 0.2

1.37 ± 0.2

p value

< 0.001**

0.02*

0.90

0.24

0.001*

0.02*

Cohen’s d

0.30a

0.20a

0

0.10

0.30a

0.20a

Fat, g/100 mL

\( \overline{x}\pm s \)

4.06 ± 0.9

4.39 ± 1.1

4.06 ± 0.9

4.57 ± 1

4.06 ± 0.9

4.00 ± 0.7

4.39 ± 1.1

4.57 ± 1.0

4.39 ± 1.1

4.00 ± 0.7

4.57 ± 1.0

4.00 ± 0.7

p value

0.04*

0.001*

0.65

0.28

0.02*

< 0.001**

Cohen’s d

0.33a

0.50b

0.07

0.17

0.42a

0.66b

Carbohydrate, g/100 mL

\( \overline{x}\pm s \)

7.39 ± 0.2

7.33 ± 0.3

7.39 ± 0.2

7.33 ± 0.2

7.39 ± 0.2

7.37 ± 0.2

7.33 ± 0.3

7.33 ± 0.2

7.33 ± 0.3

7.37 ± 0.2

7.33 ± 0.2

7.37 ± 0.2

p value

0.12

0.14

0.40

0.88

0.27

0.22

Cohen’s d

0.24a

0.24a

0.08

0

0.16

0.20a

Energy, kcal/ 100 mL

\( \overline{x}\pm s \)

74.42 ± 9.1

77.58 ± 10.0

74.42 ± 9.1

79.18 ± 9.7

74.42 ± 9.1

73.89 ± 6.8

77.58 ± 10.0

79.18 ± 9.7

77.58 ± 10.0

73.89 ± 6.8

79.18 ± 9.7

73.89 ± 6.8

p value

0.03*

< 0.001**

0.59

0.29

0.01*

< 0.001**

 

Cohen’s d

0.33a

0.51b

0.07

0.16

0.43a

0.63b

  1. \( \overline{x} \) ± s mean value ± standard deviation; Cohen’s d – Cohen’s d effect size
  2. a – small effect size, b medium effect size; significant differences are highlighted in bold (*p < 0.05; **p < 0.001)